Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patients.

ABSTRACT:

Background/aims

Amongst numerous travellers to high altitude (HA) are many with the highly prevalent COPD, who are at particular risk for altitude-related adverse health effects (ARAHE). We then investigated the hypoxia-altitude simulation test (HAST) to predict ARAHE in COPD patients travelling to altitude.

Methods

This prospective diagnostic accuracy study included 75 COPD patients: 40 women, age 58±9 years, forced expiratory volume in 1 s (FEV₁) 40-80% pred, oxygen saturation measured by pulse oximetry (S _pO2 ) ≥92% and arterial carbon dioxide tension (P _aCO2 ) <6 kPa. Patients underwent baseline evaluation and HAST, breathing normobaric hypoxic air (inspiratory oxygen fraction (F _IO2

SUBMITTER: Bauer M 

PROVIDER: S-EPMC10009702 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature