R_1ρ dispersion in white matter correlates with quantitative metrics of cognitive impairment.

ABSTRACT: Much previous neuroimaging research in Alzheimer^'s disease has focused on the roles of amyloid and tau proteins, but recent studies have implicated microvascular changes in white matter as early indicators of damage related to later dementia. We used MRI to derive novel, non-invasive measurements of R_1ρ dispersion using different locking fields to characterize variations of microvascular structure and integrity in brain tissues. We developed a non-invasive 3D R_1ρ dispersion imaging technique using different locking fields at 3T. We acquired MR images and cognitive assessments of participants with mild cognitive impairment (MCI) and compared them to age-matched healthy controls in a cross-sectional study. After providing informed consent, 40 adults aged 62 t

SUBMITTER: Adelnia F 

PROVIDER: S-EPMC10009712 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature