Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.

ABSTRACT:

Objective

Obesity and related diseases are becoming a growing risk for public health around the world due to the westernized lifestyle. Sema7A, an axonal guidance molecule, has been known to play a role in neurite growth, bone formation, and immune regulation. Whether Sema7A participates in obesity and metabolic diseases is unknown. As several SNPs in SEMA7A and its receptors were found to correlate with BMI and metabolic parameters in the human population, we investigated the potential role of Sema7A in obesity and hepatic steatosis.

Methods

GWAS and GEPIA database was used to analyze SNPs in SEMA7A and the correlation of Sema7A expression with lipid metabolism related genes. Sema7A^-/- mice and recombinant Sema7A (rSema7A) were used to study the role of Sema7A in

SUBMITTER: Lu Q 

PROVIDER: S-EPMC10009717 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature