Ontology highlight
ABSTRACT:
SUBMITTER: Choi M
PROVIDER: S-EPMC10009780 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Choi Mihwa M Schneeberger Marc M Fan Wei W Bugde Abhijit A Gautron Laurent L Vale Kevin K Hammer Robert E RE Zhang Yuan Y Friedman Jeffrey M JM Mangelsdorf David J DJ Kliewer Steven A SA
Cell metabolism 20230301 3
Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. In this report, we show that the hormone FGF21, which is strongly induced by ethanol in murine and human liver, stimulates arousal from intoxication without changing ethanol catabolism. Mice lacking FGF21 take longer than wild-type littermates to recover their righting reflex and balance following ethanol exposure. Conversely, pharmacologic FGF21 administration reduces ...[more]