Controlling Ibrutinib's Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity.

ABSTRACT: Ibrutinib is a covalent BTK inhibitor that is approved for several indications in oncology. Ibrutinib possesses significant off-target activities toward many kinases, often leading to adverse events in patients. While there have been robust medicinal chemistry efforts leading to more selective second-generation BTK inhibitors, there remains a need for new strategies to rapidly improve the selectivity of kinase inhibitors. An analysis of PDB data revealed that ibrutinib binds BTK in dihedral conformations that are orthogonal of ibrutinib's predicted low energy conformational range. Synthesis of a series of analogues with ground state conformations shifted toward orthogonality led to the discovery of an analogue with two incorporated ortho-methyl groups that possessed markedly increas

SUBMITTER: Toenjes ST 

PROVIDER: S-EPMC10009787 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature