Non-eosinophilic asthma in nonsteroidal anti-inflammatory drug exacerbated respiratory disease.

ABSTRACT:

Background

The cellular inflammatory pattern of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is heterogeneous. However, data on the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N-ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management.

Methods

Induced sputum was collected from patients with N-ERD. Sixty six patients (49.6% of 133 N-ERD) with NEA were included in the hierarchical cluster analysis based on clinical and laboratory data. The quality of clustering was evaluated using internal cluster validation with different indices and a practical decision tree was proposed to simplify stratification of pat

SUBMITTER: Mastalerz L 

PROVIDER: S-EPMC10009799 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature