An epigenetic mechanism for differential maturation of amygdala-prefrontal connectivity in childhood socio-emotional development.

ABSTRACT: Functional connectivity between the amygdala and the medial prefrontal cortex (mPFC) has been identified as a neural substrate of emotion regulation that undergoes changes throughout development, with a mature profile typically emerging at 10 years of age. Maternal bonding in childhood has been shown to buffer amygdala reactivity and to influence the trajectory of amygdala-mPFC coupling. The oxytocinergic system is critical in the development of social behavior and maternal bonding. Early-life parental care influences the methylation status of the oxytocin receptor (OXTRm) in animal models and humans, and higher OXTRm is associated with lower amygdala-PFC functional connectivity in adults. Using a neuroimaging-epigenetic approach, we investigated saliva-derived OXTRm as a biological marker

SUBMITTER: Skyberg AM 

PROVIDER: S-EPMC10009823 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature