Purpose in life promotes resilience to age-related brain burden in middle-aged adults.

ABSTRACT:

Background

Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting resilience, as the capacity of the brain to maintain cognition and function with aging and disease, is paramount. In Alzheimer's disease (AD), education and occupation are typical cognitive reserve proxies. However, the importance of psychological factors is being increasingly recognized, as their operating biological mechanisms are elucidated. Purpose in life (PiL), one of the pillars of psychological well-being, has previously been found to reduce the deleterious effects of AD-related pathological changes on cognition. However, whether PiL operates as a resilience factor in middle-aged individuals and what are the underlying neural me

SUBMITTER: Abellaneda-Perez K 

PROVIDER: S-EPMC10009845 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature