α-Glucosidase inhibitory activities of flavonoid derivatives isolated from Bouea macrophylla: in vitro and in silico studies.

ABSTRACT: In continuation of our search for bioactive compounds from the Bouea macrophylla (B. macrophylla) plant, we describe herein eight flavonoid-type compounds including mearsetin (1), mearnsitrin (2), kampferol (3), afzelin (4), quercetin (5), quercitrin (6), myricitin (7), and naringenin (8) with the aim of investigating their antidiabetic properties. Compounds 3 and 5 were selected for aromatic bromination to provide two new products 3a and 5a, respectively. All compounds showed promising α-glucosidase inhibition, with IC₅₀ values ranging from 9.2 to 266 μM apart from compound (2). Remarkably, compound 5a, 8-bromoquercetin, showed the highest inhibition activity, and it was thirty-seven times better than the standard drug acarbose. Pose 261/compound 5a interacted wel

SUBMITTER: Nguyen NH 

PROVIDER: S-EPMC10009879 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature