Ontology highlight
ABSTRACT:
SUBMITTER: Xie Q
PROVIDER: S-EPMC10009997 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Xie Qinya Q Bozzo Caterina Prelli CP Eiben Laura L Noettger Sabrina S Kmiec Dorota D Nchioua Rayhane R Niemeyer Daniela D Volcic Meta M Lee Jung-Hyun JH Zech Fabian F Sparrer Konstantin M J KMJ Drosten Christian C Kirchhoff Frank F
iScience 20230313 4
Opposing effects of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) on SARS-CoV-2 infection have been reported. The reasons for this are unclear and the role of IFITMs in infection of other human coronaviruses (hCoVs) remains poorly understood. Here, we demonstrate that endogenous expression of IFITM2 and/or IFITM3 is critical for efficient replication of SARS-CoV-1, SARS-CoV-2 and hCoV-OC43 but has little effect on MERS-, NL63-and 229E-hCoVs. In contrast, overexpression of IFITMs ...[more]