Multisystem ALK-positive histiocytosis: a multi-case study and literature review.

ABSTRACT:

Background

Anaplastic lymphoma kinase (ALK)-positive histiocytosis, a novel rare histiocytic proliferation, was first described in 2008; it occurs in early infancy with liver and hematopoietic involvement. The spectrum was subsequently broadened to include localized diseases in older children and young adults. However, its full clinicopathological features and molecular lineage have not been fully elucidated.

Results

Here, we report four cases of multisystem ALK-positive histiocytosis without hematopoietic involvement. Clinically, three patients were adults aged between 32 and 51 years. Two patients', whose main manifestations were intracranial mass and numerous micronodules in the thoracoabdominal cavity organs and skin papules respectively, had a partial response to ALK in

SUBMITTER: Liu W 

PROVIDER: S-EPMC10010018 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature