Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants.

ABSTRACT:

Background

Childhood maltreatment is associated with depression and cardiometabolic disease in adulthood. However, the relationships with these two diseases have so far only been evaluated in different samples and with different methodology. Thus, it remains unknown how the effect sizes magnitudes for depression and cardiometabolic disease compare with each other and whether childhood maltreatment is especially associated with the co-occurrence ("comorbidity") of depression and cardiometabolic disease. This pooled analysis examined the association of childhood maltreatment with depression, cardiometabolic disease, and their comorbidity in adulthood.

Methods

We carried out an individual participant data meta-analysis on 13 international observational studies (N = 217,929). Ch

SUBMITTER: Souama C 

PROVIDER: S-EPMC10010035 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature