HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway.

ABSTRACT:

Background

Lung adenocarcinoma is one of the most common tumors, and cisplatin is frequently used in treating lung adenocarcinoma patients. This study aimed to look into the roles and mechanisms of HNF4G in cisplatin resistance of lung adenocarcinoma.

Materials & methods

Cisplatin resistance and gene expression data of 542 cell lines from the CTRP and CCLE databases were analyzed. HNF4G expression was detected in the lung adenocarcinoma cell lines after treatment with various concentrations of cisplatin. Cisplatin sensitivity curves were detected in cells that overexpressed or knocked down HNF4G. The ChIP-Seq data were then analyzed to identify the targets of HNF4G involved in cisplatin resistance. Expression and phosphorylation of the MAPK6/Akt pathway were detected after H

SUBMITTER: Liang J 

PROVIDER: S-EPMC10010171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature