Repurposing a DNA-Repair Enzyme for Targeted Protein Degradation.

ABSTRACT: Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells. Our data demonstrate the utility of this approach to degrade fusion proteins in different localizations within living cells.

SUBMITTER: Fredlender C 

PROVIDER: S-EPMC10010263 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature