Repurposing a DNA-Repair Enzyme for Targeted Protein Degradation.
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ABSTRACT:
SUBMITTER: Fredlender C
PROVIDER: S-EPMC10010263 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Repurposing a DNA-Repair Enzyme for Targeted Protein Degradation.
Fredlender Callie C Levine Samantha S Zimak Jan J Spitale Robert C RC
Chembiochem : a European journal of chemical biology 20220624 19
Herein we present the exploration of the utility of DNA demethylase enzymes for targeted protein degradation. Novel benzylguanine substrates are characterized for their ability to control protein degradation in cells. Our data demonstrate the utility of this approach to degrade fusion proteins in different localizations within living cells. ...[more]
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