Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles.

ABSTRACT: Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer with different racial backgrounds harbored distinct immune cell profiles in the tumor microenvironment. Compared with African Americans (AA), Caucasian Americans (CA) exhibited increased immune cell infiltration and vasculature, and increased survival. Changes of survival and immune profile were most pronounced among active smokers and nonsmokers, compared with former smokers and total patients. Neighborhood analysis showed that immune cells accumulated around cancer cells in CAs but not AAs. Our findings reveal intrinsic biological differences between A

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10010305 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature