Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.

ABSTRACT: Inhibiting the androgen receptor (AR), a ligand-activated transcription factor, with androgen deprivation therapy is a standard-of-care treatment for metastatic prostate cancer. Paradoxically, activation of AR can also inhibit the growth of prostate cancer in some patients and experimental systems, but the mechanisms underlying this phenomenon are poorly understood. This study exploited a potent synthetic androgen, methyltestosterone (MeT), to investigate AR agonist-induced growth inhibition. MeT strongly inhibited growth of prostate cancer cells expressing AR, but not AR-negative models. Genes and pathways regulated by MeT were highly analogous to those regulated by DHT, although MeT induced a quantitatively greater androgenic response in prostate cancer cells. MeT potently downregulated

SUBMITTER: Alizadeh-Ghodsi M 

PROVIDER: S-EPMC10010308 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature