Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome.

ABSTRACT: Pancreatic cancer remains a disease with unmet clinical needs and inadequate diagnostic, prognostic, and predictive biomarkers. In-depth characterization of the disease proteome is limited. This study thus aims to define and describe protein networks underlying pancreatic cancer and identify protein centric subtypes with clinical relevance. Mass spectrometry-based proteomics was used to identify and quantify the proteome in tumor tissue, tumor-adjacent tissue, and patient-derived xenografts (PDX)-derived cell lines from patients with pancreatic cancer, and tissues from patients with chronic pancreatitis. We identified, quantified, and characterized 11,634 proteins from 72 pancreatic tissue samples. Network focused analysis of the proteomics data led to identification of a tumor epithelium-

SUBMITTER: Silwal-Pandit L 

PROVIDER: S-EPMC10010336 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature