Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.

ABSTRACT: Emerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune subversion by metastatic tumours can be achieved through several mechanisms; one of the most frequently observed involves the loss of expression or mutation of genes composing the MHC-I antigen presentation machinery (APM) that yields tumours invisible to Cytotoxic T lymphocytes, the key component of the adaptive cellular immune response. Fascinating ethnographic and experimental findings indicate that cannabinoids inhibit the growth and progression of several categories of cancer; however, the mechanisms underlying these observations remain clouded in

SUBMITTER: Dada S 

PROVIDER: S-EPMC10010394 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature