Roles of gut microbiome in epilepsy risk: A Mendelian randomization study.

ABSTRACT:

Background

Recent studies have suggested an association between gut microbiomes (GMs) and epilepsy. However, the GM taxa identified in different studies are variable. In addition, observational studies cannot indicate causality. Therefore, our study aimed to explore the causal association of GMs with epilepsy and identify the most influential GM taxa.

Methods

We conducted a Mendelian randomization (MR) study using summary statistics from genome-wide association studies (GWAS) of 211 GM taxa and epilepsy. The GWAS summary statistics for 211 GM taxa (from phylum to genus level) were generated by the MiBioGen consortium, while the FinnGen consortium provided the GWAS summary statistics for epilepsy. The primary analytical method to assess causality was the inverse-variance weig

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC10010438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature