Acute asymptomatic hyponatraemia following inpatient initiation of angiotensin receptor-neprilysin inhibitor: a case report.

ABSTRACT:

Background

Utilization of sacubitril/valsartan is increasing as a component of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction (HFrEF). Common adverse effects associated with the medication such as hypotension and hyperkalaemia have been described; however, hyponatraemia is very rarely reported to have a potential association with use of the medication. In this report, we describe what we believe to be the first reported case of acute hyponatraemia likely attributable to inpatient initiation of sacubitril/valsartan.

Case summary

A 71-year-old female presented with 2 weeks of progressively worsening dyspnoea and orthopnoea. Bedside echocardiography identified a dilated cardiomyopathy with an estimated left ventricular ejection

SUBMITTER: Dean JL 

PROVIDER: S-EPMC10010475 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature