Safe and effective thrombolysis in free flap salvage: Intra-arterial urokinase infusion.

ABSTRACT: Despite the high success rate in reconstruction using free tissue transfer, flap failure is often caused by microvascular thrombosis. In a small percentage of cases with complete flap loss, a salvage procedure is performed. In the present study, the effectiveness of intra-arterial urokinase infusion through the free flap tissue was investigated to develop a protocol to prevent thrombotic failure. The retrospective study evaluated the medical records of patients who underwent salvage procedure with intra-arterial urokinase infusion after reconstruction with free flap transfer between January 2013 and July 2019. Thrombolysis with urokinase infusion was administered as salvage treatment for patients who experienced flap compromise more than 24 hours after free flap surgery. Because of an exte

SUBMITTER: Kim JH 

PROVIDER: S-EPMC10010546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature