Development and evaluation of a synthetic cathinone targeted gas chromatography mass spectrometry (GC-MS) method.

ABSTRACT: To address challenges associated with the increased prevalence of novel psychoactive substances (NPSs), laboratories often adopt new techniques or new methods with the goal of obtaining more detailed chemical information with a higher level of confidence. To demonstrate how new methods applied to existing techniques can be a viable approach, a targeted gas chromatography mass spectrometry (GC-MS) method for synthetic cathinones was developed. To create the method, a range of GC-MS parameters were first investigated using a seven-component test solution with the goal of minimizing compounds with overlapping acceptance windows by maximizing retention time differences within a reasonable runtime. Once developed, the targeted method was evaluated through several studies and was compared to a g

SUBMITTER: Sisco E 

PROVIDER: S-EPMC10010760 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature