Humoral immune response to SARS-CoV-2 in pregnant and nonpregnant women following infection.

ABSTRACT:

Background

Immune changes that occur during pregnancy may place pregnant women at an increased risk for severe disease following viral infections like SARS-CoV-2. Whether these immunologic changes modify the immune response to SARS-CoV-2 infection during pregnancy is not well understood.

Objective

This study aimed to compare the humoral immune response to SARS-CoV-2 infection in pregnant and nonpregnant women. The immune response following vaccination for SARS-CoV-2 was also explored.

Study design

In this cohort study, 24 serum samples from 20 patients infected with SARS-CoV-2 during pregnancy were matched by number of days after a positive test with 46 samples from 40 nonpregnant women of reproductive age. Samples from 9 patients who were vaccinated during pregnancy

SUBMITTER: Jacobs MB 

PROVIDER: S-EPMC10010833 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature