Longitudinal effects and environmental moderation of ALDH2 and ADH1B gene variants on substance use from age 14 to 40.

ABSTRACT: Alcohol use and dependence are strongly affected by variation in aldehyde dehydrogenase (ALDH2) and, to a lesser extent, alcohol dehydrogenase (ADH1B) genes. We use this genetic variation with an adoption design to test the causal role of alcohol use on other drug use, as well as the moderating role of adoptive parent, sibling, and peer alcohol use. Longitudinal models were run on 412 genotyped adopted individuals of East Asian ancestry with multiple assessments between ages 14 and 40. We found robust associations between alcohol frequency, quantity, and maximum drinks and ALDH2, but not ADH1B, status. The magnitude of the ALDH2 protective effect increased with age, particularly for maximum drinks, though estimates were smaller than previously reported in

SUBMITTER: Saunders GRB 

PROVIDER: S-EPMC10011021 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature