Aberrant frontal lobe "U"-shaped association fibers in first-episode schizophrenia: A 7-Tesla Diffusion Imaging Study.

ABSTRACT: Schizophrenia is believed to be a developmental disorder with one hypothesis suggesting that symptoms arise due to abnormal interactions (or disconnectivity) between different brain regions. While some major deep white matter pathways have been extensively studied (e.g. arcuate fasciculus), studies of short-ranged, "U"-shaped tracts have been limited in patients with schizophrenia, in part due to the sheer abundance of tracts present and due to the spatial variations across individuals that defy probabilistic characterization in the absence of reliable templates. In this study, we use diffusion magnetic resonance imaging (dMRI) to investigate frontal lobe superficial white matter that are present in the majority of study participants, comparing healthy controls and minimally treated patien

SUBMITTER: Kai J 

PROVIDER: S-EPMC10011060 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature