Hypothermic machine perfusion alleviates ischemia-reperfusion injury of intestinal transplantation in pigs.

ABSTRACT:

Background

Intestinal transplantation (IT) has become an important procedure for the treatment of irreversible intestinal failure. However, IT is extremely vulnerable to ischemia-reperfusion injury (IRI). Due to the limitations of static cold storage (SCS), hypothermic machine perfusion (HMP) is rapidly gaining popularity. In this study, the intestinal HMP system is established and HMP is compared with SCS.

Methods

An intestinal HMP system was built. Ten miniature pigs were randomly divided into the HMP and SCS groups, and their intestines were perfused using the HMP device and SCS, respectively, followed by orthotopic auto-transplantation. Analysis was done on the grafts between the two groups.

Results

Operation success rates of the surgery were 100% in both groups.

SUBMITTER: Hou W 

PROVIDER: S-EPMC10011072 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature