Long-term adaptive response in COVID-19 vaccine recipients and the effect of a booster dose.

ABSTRACT: We examined the immune response in subjects previously infected with SARS-CoV2 and infection-naïve 9 months after primary 2-dose COVID-19 mRNA vaccination and 3 months after the booster dose in a longitudinal cohort of healthcare workers. Nine months after primary vaccination, previously infected subjects exhibited higher residual antibody levels, with significant neutralizing activity against distinct variants compared to infection-naïve subjects. The higher humoral response was associated with higher levels of receptor binding domain (RBD)-specific IgG⁺ and IgA⁺ memory B cells. The booster dose increased neither neutralizing activity, nor the B and T cell frequencies. Conversely, infection-naïve subjects needed the booster to achieve comparable levels of neutralizin

SUBMITTER: Perico L 

PROVIDER: S-EPMC10011096 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature