Cross-reactive antibodies against Langat virus protect mice from lethal tick-borne encephalitis virus infection.

ABSTRACT:

Introduction

Naturally attenuated Langat virus (LGTV) and highly pathogenic tick-borne encephalitis virus (TBEV) share antigenically similar viral proteins and are grouped together in the same flavivirus serocomplex. In the early 1970s, this has encouraged the usage of LGTV as a potential live attenuated vaccine against tick-borne encephalitis (TBE) until cases of encephalitis were reported among vaccinees. Previously, we have shown in a mouse model that immunity induced against LGTV protects mice against lethal TBEV challenge infection. However, the immune correlates of this protection have not been studied.

Methods

We used the strategy of adoptive transfer of either serum or T cells from LGTV infected mice into naïve recipient mice and challenged them with lethal dose of T

SUBMITTER: Kubinski M 

PROVIDER: S-EPMC10011100 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature