Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications.

ABSTRACT:

Background

Patients with sepsis are at increased risk for cardiovascular complications, including myocardial infarction (MI), ischemic stroke (IS), and venous thromboembolism (VTE). Our objective is to assess whether genetic risk score (GRS) can differentiate risk for these complications.

Methods

A population-based prospective cohort of 483,177 subjects, derived from the UK Biobank, was followed for diagnosis of sepsis and its complications (MI, IS, and VTE) after the study recruitment. GRS for each complication was calculated based on established risk-associated single nucleotide polymorphisms (SNPs). Time to incident MI, IS, and VTE was compared between subjects with or without sepsis and GRS risk groups using Kaplan-Meier log-rank test and Cox-regression analysis.

Resu

SUBMITTER: McElligott B 

PROVIDER: S-EPMC10011112 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature