Blood biomarkers of secondary outcomes following concussion: A systematic review.

ABSTRACT:

Introduction

Blood biomarkers have been identified as an alternative tool for predicting secondary outcomes following concussion. This systematic review aimed to summarize the literature on blood biomarkers of secondary outcomes following concussion in both pediatric and adult cohorts.

Methods

A literature search of Embase, Medline and PubMed was conducted. Two reviewers independently assessed retrieved studies to determine inclusion in systematic review synthesis.

Results

A total of 1771 unique studies were retrieved, 58 of which were included in the final synthesis. S100B, GFAP and tau were identified as being associated with secondary outcomes following concussion. Seventeen percent of studies were performed in a solely pediatric setting.

Conclusions

Validat

SUBMITTER: Swaney EEK 

PROVIDER: S-EPMC10011122 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature