Assessment of normal myelination in infants and young children using the T1w/T2w mapping technique.

ABSTRACT:

Background

White matter myelination is a crucial process of CNS maturation. The purpose of this study was to validate the T1w/T2w mapping technique for brain myelination assessment in infants and young children.

Methods

Ninety-four patients (0-23 months of age) without structural abnormalities on brain MRI were evaluated by using the T1w/T2w mapping method. The T1w/T2w signal intensity ratio, which reflects white matter integrity and the degree of myelination, was calculated in various brain regions. We performed a Pearson correlation analysis, a LOESS regression analysis, and a 2^nd order polynomial regression analysis to describe the relationships between the regional metrics and the age of the patients (in months).

Results

T1w/T2w ratio values rapidly inc

SUBMITTER: Filimonova E 

PROVIDER: S-EPMC10011126 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature