Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations.

ABSTRACT: Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes¹. This recent study-and most other large-scale human genetics studies-was mainly composed of individuals of European (EUR) ancestry, and the generalizability of the findings in non-EUR populations remains unclear. To address this gap, we designed a custom sequencing panel of 161 genes selected based on the current knowledge of SCZ genetics and sequenced a new cohort of 11,580 SCZ cases and 10,555 controls of diverse ancestries. Replicating earlier work, we found that ca

SUBMITTER: Liu D 

PROVIDER: S-EPMC10011128 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature