Network expansion of genetic associations defines a pleiotropy map of human cell biology.

ABSTRACT: Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of candidate trait-associated genes from genome-wide association studies. Here, we performed network-based expansion of trait-associated genes for 1,002 human traits showing that this recovers known disease genes or drug targets. The similarity of network expansion scores identifies groups of traits likely to share an underlying genetic and biological process. We identified 73 pleiotropic gene modules linked to multiple traits, enriched in genes involved in processes such as protein ubiquitination and RNA processing. In contrast to gene deletion studies, pleiotropy as defined here captures specifically multicellular-related processes. We show exam

SUBMITTER: Barrio-Hernandez I 

PROVIDER: S-EPMC10011132 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature