Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues.

ABSTRACT: Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a sometimes neglected, yet common, sign and symptom with a profound effect on instrumental activities of daily living. The prevalence of cognitive impairment in multiple sclerosis varies across the lifespan and might be difficult to distinguish from other causes in older age. MRI studies show that widespread changes to brain networks contribute to cognitive dysfunction, and grey matter atrophy is an early sign of potential future cognitive decline. Neuropsychological research suggests that cognitive processing speed and episodic memory are the most frequently affected cognitive domains. Narrowing evaluation to these core areas permits brief, routine assessment in the clinical setting. Owing to its br

SUBMITTER: Benedict RHB 

PROVIDER: S-EPMC10011205 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature