Intraocular Microbiome in Diabetes and Diabetic Retinopathy: A Pilot Study.

ABSTRACT:

Introduction

The objective of this study was to compare the microbiome in the aqueous humour and gut of people with diabetes mellitus (DM) with and without diabetic retinopathy (DR).

Methods

This was a prospective controlled study. The study included 17 people undergoing intraocular surgery in their naïve eyes. Stool samples were obtained in the perioperative period; aqueous humour samples of sufficient quantity were obtained in 12 people during intraocular surgery. Dietary information was obtained using a previously validated questionnaire. The gut and aqueous humour samples were assessed for microbiome using 16S rRNA gene sequencing coupled with QIIME and R software.

Results

Aqueous humour was analysed in 12 people: 4 each healthy controls, people with DM, and peopl

SUBMITTER: Das T 

PROVIDER: S-EPMC10011241 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature