[¹⁸F]Fluoride uptake in various bone types and soft tissues in rat.

ABSTRACT:

Background

In the development of new ¹⁸F-labelled tracers, it is important to assess the amount of released [¹⁸F]fluoride taken up in the bones of experimental animals because all ¹⁸F-labelled PET-tracers are prone, to lesser or higher degree, to undergo defluorination, with subsequent release of [¹⁸F]fluoride during scanning. However, the pharmacokinetics of [¹⁸F]fluoride in bones and other organs of healthy rats have not been well documented in a comprehensive manner. We aimed to study pharmacokinetics of [¹⁸F]NaF in rats in order to increase our understanding of the biodistribution of [¹⁸F]fluoride originating from defluorination of ¹⁸F-labelled tracers. We studied [¹⁸F]fluoride up

SUBMITTER: Savisto N 

PROVIDER: S-EPMC10011276 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature