Comprehensive Analysis of microRNA Expression During the Progression of Colorectal Tumors.

ABSTRACT:

Background

No effective early diagnostic biomarkers are available for colorectal cancer (CRC). Therefore, we sought to identify new biomarkers that could identify CRC from progression as a pre-cancerous lesion to its invasive form. Recent studies have shown that microRNAs (miRs) are associated with the onset of cancer invasion and progression.

Aims

We hypothesized that the identification of miRs associated with CRC might be useful to detect this disease at early stages.

Methods

We conducted an integrated analysis of 79 isolated colorectal tumor glands, including adenomas, intramucosal cancers, and invasive CRCs that showed a microsatellite stable phenotype using GeneChip miRNA 4.0 microarray assays. The colorectal tumors we examined were divided into 2 cohorts (42 in

SUBMITTER: Sugai T 

PROVIDER: S-EPMC10011343 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature