Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption.

ABSTRACT: Compulsive alcohol drinking is a key symptom of alcohol use disorder (AUD) that is particularly resistant to treatment. An understanding of the biological factors that underly compulsive drinking will allow for the development of new therapeutic targets for AUD. One animal model of compulsive alcohol drinking involves the addition of bitter-tasting quinine to an ethanol solution and measuring the willingness of the animal to consume ethanol despite the aversive taste. Previous studies have demonstrated that this type of aversion-resistant drinking is modulated in the insular cortex of male mice by specialized condensed extracellular matrix known as perineuronal nets (PNNs), which form a lattice-like structure around parvalbumin-expressing neurons in the cortex. Several laboratories have sh

SUBMITTER: Martins de Carvalho L 

PROVIDER: S-EPMC10011443 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature