Integrins control epithelial stem cell proliferation in the Drosophila ovary by modulating the Notch pathway.

ABSTRACT: Cell proliferation and differentiation show a remarkable inverse relationship. The temporal coupling between cell cycle withdrawal and differentiation of stem cells (SCs) is crucial for epithelial tissue growth, homeostasis and regeneration. Proliferation vs. differentiation SC decisions are often controlled by the surrounding microenvironment, of which the basement membrane (BM; a specialized form of extracellular matrix surrounding cells and tissues), is one of its main constituents. Years of research have shown that integrin-mediated SC-BM interactions regulate many aspects of SC biology, including the proliferation-to-differentiation switch. However, these studies have also demonstrated that the SC responses to interactions with the BM are extremely diverse and depend on the cell type

SUBMITTER: Rincon-Ortega L 

PROVIDER: S-EPMC10011466 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature