Systematic review of NTRK 1/2/3 fusion prevalence pan-cancer and across solid tumours.

ABSTRACT: NTRK gene fusions are rare somatic mutations found across cancer types with promising targeted therapies emerging. Healthcare systems face significant challenges in integrating these treatments, with uncertainty in prevalence and optimal testing methods to identify eligible patients. We performed a systematic review of NTRK fusion prevalence to inform efficient diagnostic screening and scale of therapeutic uptake. We searched Medline, Embase and Cochrane databases on 31/03/2021. Inclusion criteria were studies reporting fusion rates in solid tumours, English language, post-2010 publication and minimum sample size. Critical appraisal was performed using a custom 11-item checklist. Rates were collated by cancer type and pooled if additional synthesis criteria were met. 160 studies were inclu

SUBMITTER: O'Haire S 

PROVIDER: S-EPMC10011574 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature