Assessment of the association between genetic factors regulating thyroid function and microvascular complications in diabetes: A two-sample Mendelian randomization study in the European population.

ABSTRACT:

Background

Observational studies have identified a possible link between thyroid function and diabetic microangiopathy, specifically in diabetic kidney disease (DKD) and diabetic retinopathy (DR). However, it is unclear whether this association reflects a causal relationship.

Objective

To assess the potential direct effect of thyroid characteristics on DKD and DR based on Mendelian randomization (MR).

Methods

We conducted an MR study using genetic variants as an instrument associated with thyroid function to examine the causal effects on DKD and DR. The study included the analysis of 4 exposure factors associated with thyroid hormone regulation and 5 outcomes. Genomewide significant variants were used as instruments for standardized freethyroxine (FT4) and thyroid-sti

SUBMITTER: Li H 

PROVIDER: S-EPMC10011638 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature