Diabetes and intervertebral disc degeneration: A Mendelian randomization study.

ABSTRACT:

Introduction

Intervertebral disc degeneration (IVDD) is an important contributor of low back pain, which represents one of the most disabling symptoms within the adult population. Recently, increasing evidence suggests the potential association between Type 2 diabetes mellitus (T2DM) and IVDD. However, the causal relationship between these two common diseases remains unclear.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal association between T2DM and IVDD. Sensitivity analysis was performed to test for heterogeneity and horizontal pleiotropy. Multivariable MR was also conducted to adjust for the effect of BMI on IVDD.

Results

A total of 128 independent single-nucleotide polymorphisms (SNPs) that were significantly associat

SUBMITTER: Jin P 

PROVIDER: S-EPMC10011653 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature