BAFF induces CXCR5 expression during B cell differentiation in bone marrow.

ABSTRACT: B cell activating factor (BAFF) plays an important role in antibody production through differentiation and maturation of B cells mainly in secondary lymphoid organs. On the other hand, the role of BAFF in the bone marrow, the primary lymphoid organ of B cell development, has not been well elucidated. Here, effects of BAFF in bone marrow B cell development were examined by using BAFF-deficient mice. When mRNA expression levels of B cell differentiation markers including Cd19, Bcl2, Igμ, Il7r and Cxcr5 were compared between bone marrow of wild-type and BAFF-KO mice, a lower level of Cxcr5 expression was found in the KO mice. Additionally, protein expression of CXCR5 on IgM⁺ cells in the bone marrow was decreased by BAFF deficiency. In vitr

SUBMITTER: Koizumi H 

PROVIDER: S-EPMC10011739 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature