Extensive fibrosis in mediastinal seminoma is a diagnostic pitfall in small biopsies: two case reports.

ABSTRACT:

Background

In mediastinal biopsies that show fibrosis, the differential diagnosis includes fibrosing mediastinitis, immunoglobulin G subclass 4-related disease, Hodgkin lymphoma, as well as reactive fibrotic and inflammatory changes adjacent to other processes including neoplasms.

Cases description

We report two cases of incidentally detected mediastinal seminoma that contained extensive areas of paucicellular fibrosis, which precluded accurate preoperative biopsy diagnosis. The fibrosis consisted of mildly inflamed, densely scarred tissue with thin dilated vessels, and was present to a significant extent that is suggestive of spontaneous regression. These features are not currently described in the World Health Organization Classification of Thoracic Tumors. In both patient

SUBMITTER: Liccardi AR 

PROVIDER: S-EPMC10011866 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature