Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.

ABSTRACT:

Purpose

Acute and chronic GVHD remain major causes of transplant-related morbidity and mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). We have shown CD83 chimeric antigen receptor (CAR) T cells prevent GVHD and kill myeloid leukemia cell lines. In this pilot study, we investigate CD83 expression on GVHD effector cells, correlate these discoveries with clinical outcomes, and evaluate critical therapeutic implications for transplant recipients.

Experimental design

CD83 expression was evaluated among circulating CD4+ T cells, B-cell subsets, T follicular helper (Tfh) cells, and monocytes from patients with/without acute or chronic GVHD (n = 48 for each group), respectively. CD83 expression was correlated with survival, TRM, and relapse after alloH

SUBMITTER: Holtan SG 

PROVIDER: S-EPMC10011883 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature