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Current status and prospect of treatments for recurrent hepatocellular carcinoma.

ABSTRACT: Owing to its heterogeneous and highly aggressive nature, hepatocellular carcinoma (HCC) has a high recurrence rate, which is a non-negligible problem despite the increasing number of available treatment options. Recent clinical trials have attempted to reduce the recurrence and develop innovative treatment options for patients with recurrent HCC. In the event of liver remnant recurrence, the currently available treatment options include repeat hepatectomy, salvage liver transplantation, tumor ablation, transcatheter arterial chemoembolization, stereotactic body radiotherapy, systemic therapies, and combination therapy. In this review, we summarize the strategies to reduce the recurrence of high-risk tumors and aggressive therapies for recurrent HCC. Additionally, we discuss methods to prevent HCC recurrence and prognostic models constructed based on predictors of recurrence to develop an appropriate surveillance program.

SUBMITTER: Yang YQ

PROVIDER: S-EPMC10011906 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Current status and prospect of treatments for recurrent hepatocellular carcinoma.

Yang Yu-Qing YQ Wen Zhen-Yu ZY Liu Xiao-Yan XY Ma Zhen-Hu ZH Liu Yan-E YE Cao Xue-Ying XY Hou Li L Xie Hui H

World journal of hepatology 20230201 2

Owing to its heterogeneous and highly aggressive nature, hepatocellular carcinoma (HCC) has a high recurrence rate, which is a non-negligible problem despite the increasing number of available treatment options. Recent clinical trials have attempted to reduce the recurrence and develop innovative treatment options for patients with recurrent HCC. In the event of liver remnant recurrence, the currently available treatment options include repeat hepatectomy, salvage liver transplantation, tumor ab ...[more]

PMID: 36926237

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