Identifying Replicable Subgroups in Neurodevelopmental Conditions Using Resting-State Functional Magnetic Resonance Imaging Data.

ABSTRACT:

Importance

Neurodevelopmental conditions, such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), have highly heterogeneous and overlapping phenotypes and neurobiology. Data-driven approaches are beginning to identify homogeneous transdiagnostic subgroups of children; however, findings have yet to be replicated in independently collected data sets, a necessity for translation into clinical settings.

Objective

To identify subgroups of children with and without neurodevelopmental conditions with shared functional brain characteristics using data from 2 large, independent data sets.

Design, setting, and participants

This case-control study used data from the Province of Ontario Neurodevelopmental (

SUBMITTER: Vandewouw MM 

PROVIDER: S-EPMC10011941 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature