Analysis of differentially expressed genes related to cerebral ischaemia in young rats based on the Gene Expression Omnibus database

ABSTRACT:

BACKGROUND

The incidence rate of cerebral infarction in young people is increasing day by day, the age of onset tends to be younger, and its internal pathogenesis and mechanism are very complicated, which leads to greater difficulties in treatment. Therefore, it is essential to analyze the key pathway that affects the onset of cerebral infarction in young people from the perspective of genetics.

AIM

To compare the differentially expressed genes in the brain tissue of young and aged rats with middle cerebral artery occlusion and to analyse their effect on the key signalling pathway involved in the development of cerebral ischaemia in young rats.

METHODS

The Gene Expression Omnibus 2R online analysis tool was used to analyse the differentially expressed genes in th

SUBMITTER:  

PROVIDER: S-EPMC10011979 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature