Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease.

ABSTRACT:

Importance

Cross-sectional evidence implicates high prevalent frailty in patients with Parkinson disease (PD), whereas the longitudinal association remains unknown.

Objectives

To examine the longitudinal association of the frailty phenotype with the development of PD and to explore the modification role of genetic risk of PD in such an association.

Design, setting, and participants

This prospective cohort study launched in 2006 to 2010 with a follow-up of 12 years. Data were analyzed from March 2022 to December 2022. The UK Biobank recruited over 500 000 middle-aged and older adults from 22 assessment centers across the United Kingdom. Participants who were younger than 40 years (n = 101), diagnosed with dementia or PD at baseline, and developed dementia, PD, or died

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC10012040 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature