Identification of potential biomarkers and therapeutic targets for posttraumatic acute respiratory distress syndrome

ABSTRACT:

Background

Despite improved supportive care, posttraumatic acute respiratory distress syndrome (ARDS) mortality has improved very little in recent years. Additionally, ARDS diagnosis is delayed or missed in many patients. We analyzed co-differentially expressed genes (co-DEGs) to explore the relationships between severe trauma and ARDS to reveal potential biomarkers and therapeutic targets for posttraumatic ARDS.

Methods

Two gene expression datasets (GSE64711 and GSE76293) were downloaded from the Gene Expression Omnibus. The GSE64711 dataset included a subset of 244 severely injured trauma patients and 21 healthy controls. GSE76293 specimens were collected from 12 patients with ARDS who were recruited from trauma intensive care units and 11 age- and sex-matched healthy v

SUBMITTER: Qi P 

PROVIDER: S-EPMC10012314 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature